ERECTILE DYSFUNCTION
Erectile Dysfunction (ED) is a type of sexual function disorder seen when an erection (hardening) at a sufficient level for satisfying sexual performance cannot be achieved or maintained.
The prevalence of erectile dysfunction, which generally increases with age, involves many risk factors in its formation. ED development can be seen due to various factors that are vasculogenic, neurological, hormonal, or psychogenic.
Cardiovascular Diseases (CVD)
- Diabetes (Diabetes Mellitus)
- Hypertension
- Obesity
- Smoking
- Old Age
- Benign Prostate Hyperplasia
- Chronic Prostatitis
- Chronic Kidney Insufficiency
The treatment of Erectile Dysfunction is generally divided into three groups: surgical treatments, non-surgical treatments, and other treatments.
The most commonly preferred method in ED treatment is medical treatments. In medical treatments, Phosphodiesterase-5 inhibitors (PDE5-i) and hormonal treatments stand out. PDE5-i is the first line of treatment in all guidelines for ED treatment.
Nitric oxide (NO) is a chemical compound that plays an important role in regulating the mechanism of action of cGMP (cyclic guanosine monophosphate), a molecule that increases blood flow by causing relaxation in the smooth muscles of the vessels in the penis and enables erection.
PDE5i, by preserving the structure of cGMP and NO activity, supports erection. PDE5i does not initiate an erection, it ensures the maintenance of an erection. Therefore, in order for an erection to be fully achieved and maintained, hormonal treatments are applied in addition to PDE5i treatment.
LEPIGRA
Lepigra is a supplemental food in tablet form that shows effectiveness in the treatment of Erectile Dysfunction (ED).
| Components | Amount (1 Tablet) (mg) |
| Maca (Lepidium Meyenii) Extract | 500 |
| Korean Panax Ginseng Extract | 400 |
| Tribulus Terrestris Extract | 200 |
| Epimedium (Horny Goat Weed) Extract | 50 |
| L-Arginine | 200 |
Epimedium: Epimedium (Horny Goat Weed) is an aphrodisiac plant species used to treat various conditions and improve sexual function in traditional medicine. It is a flowering plant that grows in Asia and some regions of the Mediterranean. It is also known as Horny Goat Weed.
The bioactive component Icariin in Epimedium is a substance known to improve cardiovascular function, hormone regulation, modulation of immunological function, and anti-tumor activity. Icariin acts as a phosphodiesterase-5 inhibitor (PDE5i). As a PDE5i, it stimulates the NO/cGMP pathway, allowing smooth muscle relaxation, dilation of blood vessels, and increased blood flow to the penis. This provides a significant effect in achieving an erection.
Maca (Lepidium Meyenii): Maca (Lepidium Meyenii): Maca is a root of a plant belonging to the Brassica family that grows in the Andes Mountains. It has been used for over 2000 years as a food supplement in the treatment of various diseases. Due to its aphrodisiac effect, Maca, which is often preferred to improve sexual functions, is also used to increase fertility, energy, mental concentration, and physical immunity. It is also effective in improving mood and regulating alertness. Maca, by helping to regulate hormone secretion, provides a significant effect in increasing libido and improving sexual function in men. In this way, it is effective in ED treatment.
Korean Panax Ginseng: Ginseng, known as the king of all plants, is a plant species used for thousands of years as a traditional medicine for treating diseases in East Asian countries. It has been used as an aphrodisiac to increase sexual performance for many years.
Ginseng consists of biologically active compounds called ginsenosides and ginseng saponins. Both compounds are known to increase the release of nitric oxide (NO), thereby causing the penis's smooth muscles to relax and triggering an erection. Due to this effect on sexual function, it is often used in the treatment of erectile dysfunction.
L-Arginine:It is a type of amino acid that plays a part in many aspects of human physiology and metabolism. L-Arginine plays a significant role in the synthesis of nitric oxide, which relaxes blood vessels and allows more blood to flow from the arteries. In this way, it has a crucial effect in treating cardiovascular disorders and male infertility. Due to its role in NO synthesis, it causes the smooth muscles in the penis to relax, triggers an erection, and is a significant helper in the treatment of erectile dysfunction.
Tribulus Terrestris: It is a plant discovered in certain regions of Greece, China, and India, and is recognized for its ability to improve physical performance and sexual activity. For many years, it has been used not only to increase fertility, enhance libido, and improve erectile function but also to alleviate infections and inflammation. It increases the concentration of androgen receptors in cells, thus helping the body become more sensitive to the testosterone hormone.
Numerous studies have shown that Tribulus Terrestris significantly increases libido and serum testosterone levels, thereby aiding in the achievement of an erection.
While the most preferred medical methods in ED treatment serve only as PDE5i, LEPIGRA promotes an increase in testosterone and libido, initiating and sustaining an erection, and it also facilitates the maintenance of the erection with its PDE5i characteristic and role in NO synthesis. Due to these properties of the components it contains, LEPIGRA offers a comprehensive treatment support for erectile dysfunction.