| Components | Amount (1 Tablet) | Amount (2 Tablets) |
| D-mannose | 250 mg | 500mg |
| Quercetin | 60mg (76 mg) | 120mg |
| Vitamin C | 12mg | 24mg |
Sistinon Components
Cranberry: Cranberry has been traditionally used frequently in urinary tract infections for many years. It contains high amounts of vitamin C in its fruits. It has the potential to prevent bacteria from adhering to the urinary mucosa.
Proanthocyanidin (PAC): What is important is the amount of the component called proanthocyanidin (PAC) found in Cranberry. According to studies, the daily amount to be taken is min. It is stated as 72 mg.
D-mannose: D-mannose, a sugar component, is another agent that aims to prevent bacteria from causing infection.
Quercetin: It is a herbal ingredient found in many different fruits and vegetables and has been shown in clinical studies to have an anti-inflammatory effect.
Vitamin C: Vitamin C, known for its antioxidant properties, attracts attention with its antibacterial activity and ensures that the cranberry is not affected by storage conditions.
Frequently Asked Questions About Urinary Tract Infection and Sistinon
Under normal conditions, there are no microorganisms in the urinary (excretory) system. If intestinal bacteria (enteric bacteria) come into contact with the urethra (the channel through which urine is excreted), they attach there and multiply, causing infection. They progress from this area to the bladder and cause bladder inflammation (cystitis). If the infection is left untreated, it may spread to the urinary system and cause more serious problems.
Why are Urinary Tract Infections (UTI) more common in women than in men?
UTI differs between men and women because women’s urethra (the channel through which urine is removed from the body) is shorter and closer to the external genital area than men. This anatomical structure facilitates access of pathogens to the bladder and increases the risk of infection.
What are the effects of genital hygiene and product use on urinary tract health?
Proper genital hygiene practices and the use of appropriate hygiene products can reduce the risk of Urinary Tract Infection (UTI) by preventing the growth of harmful bacteria. The use of wrong products may disrupt the natural flora of the genital area and increase the risk of infection.
What is the impact of life stages such as sexual activity and menopause on Urinary Tract Infection (UTI)?
Sexual activity may increase the entry of pathogens into the urethra and the resulting risk of Urinary Tract Infection (UTI). Decreasing estrogen levels during menopause can lead to changes in vaginal pH and disruption of natural flora, increasing the risk of infection.
What are the special extensions that enable E. Coli and other bacterial species to adhere to the urethra, and what role does this adhesion process play in the formation of infection?
E. coli and some other types of bacteria use special appendages called fimbriae. These extensions enable bacteria to adhere to the urethra and bladder walls and constitute the first step of infection.
How can symptoms such as dysuria, frequent urination, cloudy urine and hematuria, which are the most common symptoms of Urinary Tract Infection (UTI), affect daily quality of life?
These symptoms can negatively affect daily activities and sleep patterns due to the need to go to the toilet frequently and the feeling of discomfort. This may reduce the person’s overall quality of life.
How does antibiotic resistance pose a challenge in the treatment of Urinary Tract Infection (UTI)?
Antibiotic resistance limits treatment options and makes infections difficult to control. Conscious use of antibiotics helps prevent unnecessary use and reduce the development of resistance.
What is the role of food supplements such as Sistinon in the prevention and treatment of Urinary Tract Infection (UTI)?
Food supplements such as Sistinon can support the prevention and treatment of UTI with the natural ingredients they contain. For example, D-mannose found in Sistinon reduces the binding ability of bacteria that adhere to the urinary tract walls, helping to remove them from the body. In this way, it helps prevent the progression of the infection and reduce the severity of the existing infection. Supplements may also play a prophylactic (protective) role by boosting the immune system and supporting urinary tract health, especially in cases of recurrent UTIs.
What is the inhibitory effect of Cranberry on bacterial adhesion and the importance of the proanthocyanidin (PAC) component it contains?
The proanthocyanidin (PAC) contained in cranberry reduces the risk of infection by preventing bacteria, especially E. coli, from adhering to the urinary tract walls. Blocking adhesion prevents bacteria from colonizing the body and spreading into the urinary tract. Studies have shown that the PAC in cranberry has a protective effect against urinary tract infections and that taking at least 72 mg of PAC daily is sufficient to provide this protective effect.
What is the role of quercetin in relieving symptoms of Urinary Tract Infection (UTI) with its anti-inflammatory properties and in which fruits and vegetables is this ingredient found?
Quercetin is known for its powerful anti-inflammatory properties and may help relieve UTI symptoms. By reducing inflammation, it can relieve symptoms such as burning and pain during urination. Quercetin is found naturally in many fruits and vegetables, such as onions, apples, green tea, grapes, cherries, blackberries and strawberries.
How does Vitamin C fit into diets to prevent Urinary Tract Infection (UTI) and how does it support the effectiveness of Cranberry?
Vitamin C can prevent the proliferation of bacteria by maintaining the acidic environment of urine and thus help prevent urinary tract infections. The acidic environment makes it difficult for bacteria to attach to the urinary system and cause infection. Vitamin C also strengthens the antioxidant effect of cranberry and supports the immune system, providing protection against infections in general. This interaction creates an important synergy in the prevention of UTI.
How to use Sistinon?
The recommended daily use of Sistinon is 1-2 tablets with meals.
SOURCES
“Cranberries for preventing urinary tract infections,” Cochrane Database of Systematic Reviews. https://www.cochrane.org/CD001321/RENAL_cranberries-preventing-urinary-tract-infections.
“A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity,” Phytochemistry https://www.sciencedirect.com/science/article/abs/pii/S0031942205002499
“D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial,” World Journal of Urology https://pubmed.ncbi.nlm.nih.gov/23633128/
“Quercetin, Inflammation and Immunity,” Nutrients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/
“Vitamin C and Immune Function,” Nutrients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/